Over the last decade there has been a remarkable increase in the number of scientific conferences and societies that focus almost exclusively on tumor metabolism and growth factors associated with metabolic signaling. Of particular relevance is the intersection of metabolism with epigenetic control and metabolic reprogramming of aberrant signaling pathways that promote the Warburg effect. This renewed interest in the cause and consequences of the Warburg effect has invigorated cancer research and promises to redirect our efforts down a path that will translate into more effective cancer treatment and prevention strategies.