Course Objective: To review the history of chiropractic and mental health, to present contemporary evidence supporting the effects of chiropractic care on persons with mental health issues, and to describe the putative neurobiological processes involved. Course Objective: To review the history of chiropractic and mental health, to present contemporary evidence supporting the effects of chiropractic care on persons with mental health issues, and to describe the putative neurobiological processes involved. Description: The chiropractic profession has a long history of acknowledging the relationship between nervous system function and mental health. This presentation reviews the history of chiropractic involvement in mental health issues and the putative neurobiological mechanisms associated with vertebral subluxation and dysregulation of the autonomic nervous system. These mechanisms include autonomic dysregulation, compromised cerebrospinal fluid CSF flow, altered stress responsivity, dysafferentation, neuroplasticity, dyskinesia, dysponesis, and changes in heart rate variability.