The purpose of this lecture is to present the fundamentals of an integrative neuroscience-forward clinical framework for addressing pain and musculoskeletal injury presentations post-MVA. The presenters will present a rational framework for approaching painful musculoskeletal conditions that is consistent with current guidelines for pain management. Specific therapeutic modalities will be presented. These include modalities including LLLT, nutrition, topical therapies, receptor-based therapy, joint mobilization, vestibular therapies and other therapies that may be utilized in acute injury and post-concussion syndromes. Assessment and documentation for MVA related injuries as well as using objective biomarkers for outcome assessment will be utilized.