What do Alzheimer’s disease, arthritis, and metabolic disorders have in common? They can all be induced by systemic gut bacterial toxins. The pathogens involved in gut dysbiosis possess inflammatory toxins such as lipopolysaccharides LPS and cytolethal distending toxins CDT. The release of these toxins in the gut opens intestinal tight junctions and degrades epithelial cells allowing for unfettered infiltration of LPS and CDT into the periphery. Once in circulation, the inflammatory LPS and CDT can travel throughout the body, opening the blood-brain barrier, inflaming joint tissues, dysregulating the thyroid, and initiating insulin resistance. This therapeutic opportunity applies to many of the patients seen each week. Detection of systemic bacterial toxins can guide an appropriate gut-healing protocol. Repairing and maintaining the intestinal barrier is a key component in combating many extra-intestinal disorders. Learning Objectives: 1 Assess triggers, barrier integrity, neuron regeneration, and neuronal degeneration 2 Discuss nutritional protocols for Alzheimer's and metabolic disorders and their common links 3 Explain the gut and brain axis for better management of autoimmune disorders 4 Identify modern lifestyles and environmental triggers that are affecting the gut-brain axis and contributing to the neuroautoimmune epidemic This presentation will explore the commonalities between Alzheimer’s disease, arthritis, and metabolic disorders. They can all be induced by systemic gut bacterial toxins. The pathogens involved in gut dysbiosis possess inflammatory toxins such as lipopolysaccharides LPS and cytolethal distending toxins CDT. The release of these toxins in the gut opens intestinal tight junctions and degrades epithelial cells allowing for unfettered infiltration of LPS and CDT into the periphery. Once in circulation, the inflammatory LPS and CDT can travel throughout the body, opening the blood-brain barrier, inflaming joint tissues, dysregulating the thyroid, and initiating insulin resistance. This therapeutic opportunity applies to many of the patients seen each week. Detection of systemic bacterial toxins can guide an appropriate gut-healing protocol. Repairing and maintaining the intestinal barrier is a key component in combating many extra-intestinal disorders. Learning Objectives: 1 Assess triggers, barrier integrity, neuron regeneration, and neuronal degeneration 2 Discuss nutritional protocols for Alzheimer's and metabolic disorders and their common links 3 Explain the gut and brain axis for better management of autoimmune disorders 4 Identify modern lifestyles and environmental triggers that are affecting the gut-brain axis and contributing to the neuroautoimmune epidemic This presentation will explore the commonalities between Alzheimer’s disease, arthritis, and metabolic disorders. They can all be induced by systemic gut bacterial toxins. The pathogens involved in gut dysbiosis possess inflammatory toxins such as lipopolysaccharides LPS and cytolethal distending toxins CDT. The release of these toxins in the gut opens intestinal tight junctions and degrades epithelial cells allowing for unfettered infiltration of LPS and CDT into the periphery. Once in circulation, the inflammatory LPS and CDT can travel throughout the body, opening the blood-brain barrier, inflaming joint tissues, dysregulating the thyroid, and initiating insulin resistance. This therapeutic opportunity applies to many of the patients seen each week. Detection of systemic bacterial toxins can guide an appropriate gut-healing protocol. Repairing and maintaining the intestinal barrier is a key component in combating many extra-intestinal disorders. Learning Objectives: 1 Assess triggers, barrier integrity, neuron regeneration, and neuronal degeneration 2 Discuss nutritional protocols for Alzheimer's and metabolic disorders and their common links 3 Explain the gut and brain axis for better management of autoimmune disorders 4 Identify modern lifestyles and environmental triggers that are affecting the gut-brain axis and contributing to the neuroautoimmune epidemic This presentation will explore the commonalities between Alzheimer’s disease, arthritis, and metabolic disorders. They can all be induced by systemic gut bacterial toxins. The pathogens involved in gut dysbiosis possess inflammatory toxins such as lipopolysaccharides LPS and cytolethal distending toxins CDT. The release of these toxins in the gut opens intestinal tight junctions and degrades epithelial cells allowing for unfettered infiltration of LPS and CDT into the periphery. Once in circulation, the inflammatory LPS and CDT can travel throughout the body, opening the blood-brain barrier, inflaming joint tissues, dysregulating the thyroid, and initiating insulin resistance. This therapeutic opportunity applies to many of the patients seen each week. Detection of systemic bacterial toxins can guide an appropriate gut-healing protocol. Repairing and maintaining the intestinal barrier is a key component in combating many extra-intestinal disorders. Learning Objectives: 1 Assess triggers, barrier integrity, neuron regeneration, and neuronal degeneration 2 Discuss nutritional protocols for Alzheimer's and metabolic disorders and their common links 3 Explain the gut and brain axis for better management of autoimmune disorders 4 Identify modern lifestyles and environmental triggers that are affecting the gut-brain axis and contributing to the neuroautoimmune epidemic
