Course Description This course will provide an extensive literature review of microglia, neuroimmunity, and current disease that involve and underlying neuroinflammatory pathophysiology. An evidence-based model incorporating diet, nutrition, and lifestyle medicine will be presented. Clinical applications to glial priming, laboratory tests, patient history, and physical examination will be presented in detail. Learning Objectives: 1. Understand the role of glial cells in brain function 2. Review the basic concepts of neuroimmunology 3. Review the scientific literature for nutrients, dietary approached and lifestyle factors that impact neuroinfammation 4. Understand the clinical concept of glial priming 5. Learn how to identify neuroinflammation from the patient history 6. Learn examination and laboratory findings found with neuroinflammation 7. Learn how to identify neuroinflammation with MRI and other imaging studies